HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3
Copyright policy )HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3
Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.
Gene Expression Regulation, Viral, Matrin 3, Active Transport, Cell Nucleus, RNA-Binding Proteins, rev Gene Products, Human Immunodeficiency Virus, RNA binding protein, Nucleus, RNA processing, Nuclear Matrix-Associated Proteins, Virology, HIV-1, RNA Precursors, Humans, RNA, Viral, Gene expression, RNA Processing, Post-Transcriptional, PTB-Associated Splicing Factor, PSF, Rev
Gene Expression Regulation, Viral, Matrin 3, Active Transport, Cell Nucleus, RNA-Binding Proteins, rev Gene Products, Human Immunodeficiency Virus, RNA binding protein, Nucleus, RNA processing, Nuclear Matrix-Associated Proteins, Virology, HIV-1, RNA Precursors, Humans, RNA, Viral, Gene expression, RNA Processing, Post-Transcriptional, PTB-Associated Splicing Factor, PSF, Rev
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