2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
Copyright policy )2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
Significance The 2′-O methyl group in Cap-1 is essential to protect viral RNA from host interferon-induced response. We determined crystal structures of SARS-CoV-2 Nsp10/16 heterodimer in complex with substrates (Cap-0 analog and S-adenosyl methionine) and products (Cap-1 analog and S-adenosyl-L-homocysteine) at room temperature using synchrotron serial crystallography. Analysis of these structures will aid structure-based drug design against 2′-O-methyltransferase from SARS-CoV-2.
- Northwestern University United States
- Jagiellonian University Poland
- University of Chicago United States
- University of Chicago United States
- Northeastern University United States
RNA Caps, S-Adenosylmethionine, Crystallography, SARS-CoV-2, mRNA, Methyltransferases, Biological Sciences, Viral Nonstructural Proteins, RNA Cap Analogs, Methylation, S-Adenosylhomocysteine, CAP-1, Nsp10/16, Multiprotein Complexes, RNA, Viral, serial crystallography, Viral Regulatory and Accessory Proteins, RNA, Messenger, Synchrotrons
RNA Caps, S-Adenosylmethionine, Crystallography, SARS-CoV-2, mRNA, Methyltransferases, Biological Sciences, Viral Nonstructural Proteins, RNA Cap Analogs, Methylation, S-Adenosylhomocysteine, CAP-1, Nsp10/16, Multiprotein Complexes, RNA, Viral, serial crystallography, Viral Regulatory and Accessory Proteins, RNA, Messenger, Synchrotrons
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).57 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!