Membrane bound O-acyltransferases and their inhibitors
Copyright policy )Membrane bound O-acyltransferases and their inhibitors
Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.
- Imperial College London United Kingdom
Biochemistry & Molecular Biology, PROTEINS, Acylation, Lipoylation, palmitoleoylation, membrane-bound O-acyltransferases (MBOATs), porcupine (PORCN), Small Molecule Libraries, ghrelin O-acyltransferase (GOAT), SONIC-HEDGEHOG, PORCUPINE, GOAT, Animals, Humans, palmitoylation, GHRELIN, PALMITOYLATION, Science & Technology, IDENTIFICATION, Cell Membrane, Membrane Proteins, CANCER, WNT SECRETION, Ghrelin, ACYLATION, Life Sciences & Biomedicine, octanoylation, Acyltransferases, hedgehog acyltransferase (HHAT)
Biochemistry & Molecular Biology, PROTEINS, Acylation, Lipoylation, palmitoleoylation, membrane-bound O-acyltransferases (MBOATs), porcupine (PORCN), Small Molecule Libraries, ghrelin O-acyltransferase (GOAT), SONIC-HEDGEHOG, PORCUPINE, GOAT, Animals, Humans, palmitoylation, GHRELIN, PALMITOYLATION, Science & Technology, IDENTIFICATION, Cell Membrane, Membrane Proteins, CANCER, WNT SECRETION, Ghrelin, ACYLATION, Life Sciences & Biomedicine, octanoylation, Acyltransferases, hedgehog acyltransferase (HHAT)
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