Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development
Copyright policy )Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development
The two-meter-long DNA is compressed into chromatin in the nucleus of every cell, which serves as a significant barrier to transcription. Therefore, for processes such as replication and transcription to occur, the highly compacted chromatin must be relaxed, and the processes required for chromatin reorganization for the aim of replication or transcription are controlled by ATP-dependent nucleosome remodelers. One of the most highly studied remodelers of this kind is the BRG1- or BRM-associated factor complex (BAF complex, also known as SWItch/sucrose non-fermentable (SWI/SNF) complex), which is crucial for the regulation of gene expression and differentiation in eukaryotes. Chromatin remodeling complex BAF is characterized by a highly polymorphic structure, containing from four to 17 subunits encoded by 29 genes. The aim of this paper is to provide an overview of the role of BAF complex in chromatin remodeling and also to use literature mining and a set of computational and bioinformatics tools to analyze structural properties, intrinsic disorder predisposition, and functionalities of its subunits, along with the description of the relations of different BAF complex subunits to the pathogenesis of various human diseases.
- Russian Academy of Sciences Russian Federation
- University of South Florida United States
- State University System of Florida United States
- University of South Florida St. Petersburg United States
- University of Florida United States
570, Chromosomal Proteins, Non-Histone, Atp-dependent Nucleosome Remodeler, Article, chromatin remodeling, Neoplasms, Medicine and Health Sciences, Humans, Computer Simulation, Intrinsically Disordered Protein Region, BAF complex, ATP-dependent nucleosome remodeler, intrinsically disordered protein region, BAF Complex, Chromatin Remodeling, 500, 540, Chromatin Assembly and Disassembly, Gene Expression Regulation, Neoplastic, Intrinsically Disordered Proteins, Intrinsically Disordered Protein, intrinsically disorder protein, Transcription Factors
570, Chromosomal Proteins, Non-Histone, Atp-dependent Nucleosome Remodeler, Article, chromatin remodeling, Neoplasms, Medicine and Health Sciences, Humans, Computer Simulation, Intrinsically Disordered Protein Region, BAF complex, ATP-dependent nucleosome remodeler, intrinsically disordered protein region, BAF Complex, Chromatin Remodeling, 500, 540, Chromatin Assembly and Disassembly, Gene Expression Regulation, Neoplastic, Intrinsically Disordered Proteins, Intrinsically Disordered Protein, intrinsically disorder protein, Transcription Factors
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