High prevalence of cytochrome P 450 2A6*1A alleles in a black African population of Ghana
Copyright policy )High prevalence of cytochrome P 450 2A6*1A alleles in a black African population of Ghana
We investigated the frequencies of the functionally important variants of the CYP2A6 gene in black African populations.Using genomic DNA sequencing, polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR, the allele frequencies of CYP2A6 *1A, *1B, *2, *4A, *5, *6, *7, *8, *9, *10 and * 11 among 120 black Africans- including 105 Ghanaians, 12 Nigerians, 2 Ivorians and 1 Ugandan-were determined.The allele frequencies were 80.5% for CYP2A6*1A, 11.9% for CYP2A6*1B, 1.9% for CYP2A6*4A and 5.7% for CYP2A6*9 in the Ghanaian subjects. No subject homozygous for the CYP2A6*4A allele, a whole gene deletion type of polymorphism prevalent among Orientals, was found. Furthermore, CYP2A6 variants such as *2, *5, *6, *7, *8, *10 and *11 were absent in these black African populations.This study provides, for the first time, the results of the analysis of CYP2A6 allele frequency in black African populations and confirms large ethnic differences in the polymorphic CYP2A6 gene.
- University of Kansas Medical Center United States
- University of Kansas United States
- Hokkaido University Japan
- Hokkaido Bunkyo University Japan
Adult, Male, Genotype, Black People, Middle Aged, Ghana, Polymerase Chain Reaction, Mixed Function Oxygenases, Cytochrome P-450 CYP2A6, Gene Frequency, Humans, Female, Aryl Hydrocarbon Hydroxylases, Polymorphism, Restriction Fragment Length, Aged
Adult, Male, Genotype, Black People, Middle Aged, Ghana, Polymerase Chain Reaction, Mixed Function Oxygenases, Cytochrome P-450 CYP2A6, Gene Frequency, Humans, Female, Aryl Hydrocarbon Hydroxylases, Polymorphism, Restriction Fragment Length, Aged
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