Mouse strains for the ubiquitous or conditional overexpression of the Flii gene
Copyright policy )Mouse strains for the ubiquitous or conditional overexpression of the Flii gene
AbstractThe gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and humans Flii expression increases with age and amelioration of FLII activity represents a possible therapeutic strategy for improved wound healing in humans. Despite analysis of Flii function in a variety of organisms we know little of the molecular mechanisms underlying Flii action. Two new murine alleles of Flii have been produced to drive constitutive or tissue‐specific expression of Flii. Each strain is able to rescue the embryonic lethality associated with a Flii null allele and to impair wound healing. These strains provide valuable resources for ongoing investigation of Flii function in a variety of biological processes. genesis 49:681–688, 2011. © 2011 Wiley‐Liss, Inc.
- King Saud University Saudi Arabia
- Australian National University Australia
- University of South Australia Australia
- Women's & Children's Health Research Institute Australia
Male, RNA, Untranslated, Genotype, gene overexpression, B ROSA26, animal experiment, Blotting, Western, Receptors, Cytoplasmic and Nuclear, wound healing, Mice, Transgenic, animal cell, animal tissue, lethality, Mice, Animals, controlled study, gene, ROSA26, mouse, Mice, Knockout, Mice, Inbred BALB C, nonhuman, Reverse Transcriptase Polymerase Chain Reaction, animal model, Gene Expression Profiling, Muscles, Myocardium, Microfilament Proteins, article, Brain, Proteins, Flii gene, Cytoskeletal Proteins, female, gene function, priority journal, null allele, Keywords: allele, mouse strain, Female, Carrier Proteins
Male, RNA, Untranslated, Genotype, gene overexpression, B ROSA26, animal experiment, Blotting, Western, Receptors, Cytoplasmic and Nuclear, wound healing, Mice, Transgenic, animal cell, animal tissue, lethality, Mice, Animals, controlled study, gene, ROSA26, mouse, Mice, Knockout, Mice, Inbred BALB C, nonhuman, Reverse Transcriptase Polymerase Chain Reaction, animal model, Gene Expression Profiling, Muscles, Myocardium, Microfilament Proteins, article, Brain, Proteins, Flii gene, Cytoskeletal Proteins, female, gene function, priority journal, null allele, Keywords: allele, mouse strain, Female, Carrier Proteins
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