Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus
Copyright policy )Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus
Abstract Recognition of self-peptide–MHC complexes by high-affinity TCRs and CD28 signaling are critical for the development of forkhead-winged helix box transcription factor 3+ regulatory T cells (Tregs) in thymus. However, the type of APCs that are responsible for selecting Tregs has remained unclear. To dissect the role of hematopoietic-derived APCs (HCs) and thymic epithelial cells (TECs) in Treg selection, we constructed bone marrow chimeras with disrupted CD28/B7 signaling in the HC or TEC compartment and analyzed the generation of Tregs in the thymus. We found that both HCs and TECs were independently able to fully reconstitute the Treg population in the thymus of bone marrow chimeras. In addition, Treg selection requires the TCR signal and CD28 costimulation presented in cis on the same APC type in vivo. This study demonstrates a new role, to our knowledge, for HCs in the development of Tregs in thymus.
- The University of Texas System United States
- The University of Texas MD Anderson Cancer Center United States
Antigen Presentation, Receptors, Antigen, T-Cell, Antigen-Presenting Cells, Bone Marrow Cells, Cell Differentiation, Epithelial Cells, Cell Separation, Thymus Gland, Flow Cytometry, T-Lymphocytes, Regulatory, Mice, Inbred C57BL, Mice, CD28 Antigens, Animals, Signal Transduction
Antigen Presentation, Receptors, Antigen, T-Cell, Antigen-Presenting Cells, Bone Marrow Cells, Cell Differentiation, Epithelial Cells, Cell Separation, Thymus Gland, Flow Cytometry, T-Lymphocytes, Regulatory, Mice, Inbred C57BL, Mice, CD28 Antigens, Animals, Signal Transduction
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