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The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1993 United Kingdom English Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 90, pages 143-147 (issn: 0027-8424, eissn: 1091-6490,

Authors: Schubert, F. R.; Nieselt-Struwe, Katja; Gruss, Peter;

doi: 10.1073/pnas.90.1.143

pmid: 8093557

pmc: PMC45616

The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution.

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Abstract

The developmental control genes containing an Antennapedia-type homeobox are clustered in insects and vertebrates. The evolution of these genes was studied by the construction of evolutionary trees and by statistical geometry in sequence space. The comparative analysis of the homeobox sequences reveals the subdivision of the Antennapedia-type homeobox genes into three classes early in metazoan evolution. This observation suggests an important function of these genes even in the most primitive metazoans. Subsequent duplication events generated a cluster of at least five homeobox genes in the last common ancestor of insects and vertebrates. These genes later independently gave rise to the 13 groups of paralogous genes in vertebrates and to the 11 Antennapedia-type genes in the Drosophila complexes.

Country

United Kingdom

Related Organizations

Max Planck Society
Germany
University of Portsmouth
United Kingdom
Max Planck Institute for Multidisciplinary Sciences
Germany

Keywords

612, Genetic, Models, /dk/atira/pure/core/subjects/biomedicalsciences, Homeobox, Animals, Drosophila Proteins, Humans, Codon, Homeodomain Proteins, Base Sequence, Models, Genetic, Genes, Homeobox, Biomedical Sciences, Nuclear Proteins, Biological Evolution, DNA-Binding Proteins, Pyrimidines, Genes, Purines, Multigene Family, Antennapedia Homeodomain Protein, Drosophila, Transcription Factors

28 Research products, page 1 of 3

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