descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2015 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 6, pages 4,519-4,524 (issn: 2041-6520, eissn: 2041-6539,

Authors: David Y. Song; Arturo A. Pizano; Patrick G. Holder; JoAnne Stubbe; Daniel G. Nocera;

doi: 10.1039/c5sc01125f

pmid: 26504513

pmc: PMC4618407

Direct interfacial Y731 oxidation in α2 by a photoβ2 subunit of E. coli class Ia ribonucleotide reductase

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Abstract

Proton-coupled electron transfer (PCET) is a fundamental mechanism important in a wide range of biological processes including the universal reaction catalysed by ribonucleotide reductases (RNRs) in making de novo, the building blocks required for DNA replication and repair.

Related Organizations

Harvard University
United States
Massachusetts Institute of Technology
United States
Department of Chemistry and Chemical Biology
United States

Keywords

570, Chemistry, 540

11 Research products, page 1 of 2

Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase
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Modulation of Y₃₅₆ Photooxidation in E. coli Class Ia Ribonucleotide Reductase by Y₇₃₁ Across the α₂:β₂ Interface
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Cation Mediation of Radical Transfer between Trp48 and Tyr356 during O₂ Activation by Protein R2 of Escherichia coli Ribonucleotide Reductase: Relevance to R1−R2 Radical Transfer in Nucleotide Reduction?
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Site-Specific Replacement of Y₃₅₆ with 3,4-Dihydroxyphenylalanine in the β2 Subunit of E. coli Ribonucleotide Reductase
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Re(bpy)(CO)₃CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase
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Equilibration of Tyrosyl Radicals (Y₃₅₆^•, Y₇₃₁^•, Y₇₃₀^•) in the Radical Propagation Pathway of the Escherichia coli Class Ia Ribonucleotide Reductase
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Gated Proton Release during Radical Transfer at the Subunit Interface of Ribonucleotide Reductase
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Turning on ribonucleotide reductase by light-initiated amino acid radical generation
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Direct interfacial Y731 oxidation in α2 by a photoβ2 subunit of E. coli class Ia ribonucleotide reductase

Direct interfacial Y731 oxidation in α2 by a photoβ2 subunit of E. coli class Ia ribonucleotide reductase

11 Research products, page 1 of 2

Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase

Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase

A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes

Modulation of Y₃₅₆ Photooxidation in E. coli Class Ia Ribonucleotide Reductase by Y₇₃₁ Across the α₂:β₂ Interface

Cation Mediation of Radical Transfer between Trp48 and Tyr356 during O₂ Activation by Protein R2 of Escherichia coli Ribonucleotide Reductase: Relevance to R1−R2 Radical Transfer in Nucleotide Reduction?

Site-Specific Replacement of Y₃₅₆ with 3,4-Dihydroxyphenylalanine in the β2 Subunit of E. coli Ribonucleotide Reductase

Re(bpy)(CO)₃CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase

Equilibration of Tyrosyl Radicals (Y₃₅₆^•, Y₇₃₁^•, Y₇₃₀^•) in the Radical Propagation Pathway of the Escherichia coli Class Ia Ribonucleotide Reductase

Gated Proton Release during Radical Transfer at the Subunit Interface of Ribonucleotide Reductase

Turning on ribonucleotide reductase by light-initiated amino acid radical generation