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Science Signaling
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Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

Authors: Cheng, Zhang; Taylor, Brooks; Ourthiague, Diana R; Hoffmann, Alexander;

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

Abstract

Mathematical modeling and imaging analysis reveal the relative contributions of two adaptor proteins to the activation of NF-κB in macrophages.

Keywords

1.1 Normal biological development and functioning, Cells, 610, Bioengineering, Inbred C57BL, Ligands, Cell Line, Mice, Theoretical, Models, Innate, Animals, Femur, Cells, Cultured, Cultured, Inflammatory and immune system, Macrophages, Cell Membrane, Immunity, Adaptor Proteins, NF-kappa B p50 Subunit, Biological Sciences, Models, Theoretical, Immunity, Innate, Vesicular Transport, Mice, Inbred C57BL, Toll-Like Receptor 4, Adaptor Proteins, Vesicular Transport, Biochemistry and cell biology, Myeloid Differentiation Factor 88, Biochemistry and Cell Biology, Algorithms, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    109
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
109
Top 1%
Top 10%
Top 10%
Green
bronze