Organic Letters

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Organic Letters

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Organic Letters

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New Lactimidomycin Congeners Shed Insight into Lactimidomycin Biosynthesis in Streptomyces amphibiosporus

descriptionPublicationkeyboard_double_arrow_right Article 13 Nov 2007 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 9, pages 5,183-5,186 (issn: 1523-7060, eissn: 1523-7052,

Authors: Yeng Her; Jeong-Woo Seo; Jianhua Ju; Ben Shen; Si-Kyu Lim;

doi: 10.1021/ol702249g

pmid: 17997563

New Lactimidomycin Congeners Shed Insight into Lactimidomycin Biosynthesis in Streptomyces amphibiosporus

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Abstract

Lactimidomycin (LTM, 1) is a macrolide antitumor antibiotic with a glutarimide side chain from Streptomyces amphibiosporus ATCC53964. To further develop LTM and related analogues as drug candidates we have (i) improved LTM production by approximately 20 fold, (ii) identified three new metabolites (2-4) possibly involved in the LTM biosynthetic pathway; (iii) found 3 to be identical with a previously identified isomigrastatin precursor, (iv) determined the absolute stereochemistry of LTM, and (v) produced new LTM rearrangement products 2a-d and 4a-d.

Related Organizations

University of Wisconsin–Oshkosh
United States
National University
United States

Keywords

Biological Products, Molecular Structure, Macrolides, Chromatography, High Pressure Liquid, Piperidones, Streptomyces

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	30
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