Th1 Cytokine Polymorphisms in Spanish Patients With Type 1 Diabetes
Copyright policy )Th1 Cytokine Polymorphisms in Spanish Patients With Type 1 Diabetes
Several polymorphisms in regions where Th1 cytokines (IL12B and IFNG genes) are located were analyzed in 303 Spanish subjects with type 1 diabetes and compared with a control cohort (n = 548). Both groups comprised residents of the Madrid area. The haplotype frequencies were estimated by the expectation-maximization algorithm, and p values were corrected by the number of haplotypes taken into account in the study. Two haplotypes were significantly associated with the disease, one in the IL12B region (D5S2038*8/D5S1352*2/SNP1188C; OR = 3.01, p(c) = 0.0255) and another involved the IFNGgene (D12S313*9/IFNG*1; OR = 1.58, p(c) = 0.0217). Furthermore, a protective IL12B haplotype was found (D5S2038*4/D5S1352*1/SNP1188A; OR = 0.40, p(c) = 0.0405). No association was found for any of IL12B and IFNG markers individually.
Adult, Male, Polymorphism, Genetic, Adolescent, Genotype, Infant, Middle Aged, Th1 Cells, Diabetes Mellitus, Type 1, Gene Frequency, Spain, Child, Preschool, Cytokines, Humans, Female, Genetic Predisposition to Disease, Child
Adult, Male, Polymorphism, Genetic, Adolescent, Genotype, Infant, Middle Aged, Th1 Cells, Diabetes Mellitus, Type 1, Gene Frequency, Spain, Child, Preschool, Cytokines, Humans, Female, Genetic Predisposition to Disease, Child
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