Zebrafish homologue irx1a is required for the differentiation of serotonergic neurons
Copyright policy )Zebrafish homologue irx1a is required for the differentiation of serotonergic neurons
AbstractSerotonergic (5HT) neurons produce neurotransmitter serotonin, which modulates various neuronal circuits. The specification and differentiation of 5HT neurons require both extrinsic signals such as Shh and Fgf, as well as intrinsic transcription factors such as nkx2.2, mash1, phox2b, Gata2, and pet1. In this study, we show that iroquois homeodomain factor irx1a, but not irx1b, is expressed in the 5HT neurons. Knockdown of irx1a by antisense morpholino nucleotides reveals that it is a critical determinant for the differentiation of 5HT neurons in the hindbrain. However, irx1a morphants do not show a reduction of the progenitors of 5HT neurons. Hence, irx1a is not required for the initial specification but it is required for the complete differentiation of 5HT neurons. Developmental Dynamics 236:2661–2667, 2007. © 2007 Wiley‐Liss, Inc.
- City University of Hong Kong China (People's Republic of)
- University of Toronto Canada
Homeodomain Proteins, Neurons, Neurotransmitter Agents, Serotonin, Gene Expression Regulation, Developmental, Apoptosis, Zebrafish Proteins, Models, Biological, Acridine Orange, Homeobox Protein Nkx-2.2, Animals, In Situ Hybridization, Zebrafish, Developmental Biology, Fluorescent Dyes, Transcription Factors
Homeodomain Proteins, Neurons, Neurotransmitter Agents, Serotonin, Gene Expression Regulation, Developmental, Apoptosis, Zebrafish Proteins, Models, Biological, Acridine Orange, Homeobox Protein Nkx-2.2, Animals, In Situ Hybridization, Zebrafish, Developmental Biology, Fluorescent Dyes, Transcription Factors
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