Protein‐interaction mapping in search of effective drug targets
Copyright policy )Protein‐interaction mapping in search of effective drug targets
AbstractSignaling complexes and networks are being intensely studied in an attempt to discover pathways that are amenable to therapeutic intervention. A challenge in this search is to understand the effect that the modulation of a target will have on the overall function of a cell and its surrounding neighbors. Protein‐interaction mapping reveals relationships between proteins and their impact on cellular processes and is being used more widely in our understanding of disease mechanisms and their treatment. The review discusses challenges and breakthroughs in this new and evolving area and its impact on medicine. BioEssays 27:958–969, 2005. © 2005 Wiley Periodicals, Inc.
- GENENTECH INC United States
Drug Design, Protein Interaction Mapping, Drug Evaluation, Preclinical, Animals, Humans, Protein Binding, Signal Transduction, Substrate Specificity
Drug Design, Protein Interaction Mapping, Drug Evaluation, Preclinical, Animals, Humans, Protein Binding, Signal Transduction, Substrate Specificity
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).15 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!