The 5-HT3A receptor is essential for fear extinction
Copyright policy )The 5-HT3A receptor is essential for fear extinction
The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT3A receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.
- Osaka University Japan
Male, Mice, Knockout, Analysis of Variance, Electroshock, Conditioning, Classical, Brain, Fear, Brief Communication, Extinction, Psychological, Mice, Inbred C57BL, Mice, Memory, Animals, Receptors, Serotonin, 5-HT3, Maze Learning
Male, Mice, Knockout, Analysis of Variance, Electroshock, Conditioning, Classical, Brain, Fear, Brief Communication, Extinction, Psychological, Mice, Inbred C57BL, Mice, Memory, Animals, Receptors, Serotonin, 5-HT3, Maze Learning
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