DNA-repair gene variants are associated with glioblastoma survival
Copyright policy )DNA-repair gene variants are associated with glioblastoma survival
Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p < 0.05) associated with glioblastoma survival.
- University of Leeds United Kingdom
- Slagelse Hospital Denmark
- Danish Cancer Society Denmark
- Umeå University Sweden
- Copenhagen University Hospital Denmark
Adult, Male, Adolescent, DNA Repair, Genotype, Denmark, Polymorphism, Single Nucleotide, Humans, Genetic Predisposition to Disease, Aged, Cancer och onkologi, RecQ Helicases, Brain Neoplasms, Middle Aged, Prognosis, DNA-Binding Proteins, Survival Rate, MutS Homolog 2 Protein, Cancer and Oncology, Case-Control Studies, Female, Glioblastoma
Adult, Male, Adolescent, DNA Repair, Genotype, Denmark, Polymorphism, Single Nucleotide, Humans, Genetic Predisposition to Disease, Aged, Cancer och onkologi, RecQ Helicases, Brain Neoplasms, Middle Aged, Prognosis, DNA-Binding Proteins, Survival Rate, MutS Homolog 2 Protein, Cancer and Oncology, Case-Control Studies, Female, Glioblastoma
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