Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case–Control Study and Meta-analysis
Copyright policy )Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case–Control Study and Meta-analysis
Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
- Institut Pasteur France
- Institut Pasteur de Tunis Tunisia
- Institut Pasteur du Maroc Morocco
- Université Hassan 1er Morocco
Adult, Male, tRNA Methyltransferases, RNA-Binding Proteins, Cyclin-Dependent Kinase 5, Exons, Middle Aged, Polymorphism, Single Nucleotide, Introns, Diabetes Mellitus, Type 2, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Potassium Channels, Inwardly Rectifying, Genetic Association Studies, Aged
Adult, Male, tRNA Methyltransferases, RNA-Binding Proteins, Cyclin-Dependent Kinase 5, Exons, Middle Aged, Polymorphism, Single Nucleotide, Introns, Diabetes Mellitus, Type 2, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Potassium Channels, Inwardly Rectifying, Genetic Association Studies, Aged
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