Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells: Role of the Duffy antigen receptor for chemokines
Copyright policy )Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells: Role of the Duffy antigen receptor for chemokines
We investigated the effects of the chemokines IL-8 and RANTES on the activity of the Gardos channel (GC) of sickle red blood cells (SSRBCs). SSRBCs expressing the Duffy antigen receptor for chemokines (DARC) incubated under oxygenated conditions exhibit GC activation. The deoxygenation-stimulated K(+) loss via the GC is activated by the chemokines in the Duffy-positive SSRBCs. The percentage of cells with high density is 17 times higher in the Duffy-positive group. These findings are consistent with a greater susceptibility of Duffy-positive SSRBCs to inflammatory chemokines leading to GC activation and cellular dehydration and suggest a coupling, promoted by the sickling process, between DARC and the GC.
- University of the French West Indies and Guiana Guadeloupe
- Institut Pasteur France
Adult, Ion Transport, Charybdotoxin, Dehydration, Interleukin-8, Erythrocytes, Abnormal, Receptors, Cell Surface, Anemia, Sickle Cell, Intermediate-Conductance Calcium-Activated Potassium Channels, Oxygen, Potassium, Humans, Duffy Blood-Group System, Cell Shape, Chemokine CCL5
Adult, Ion Transport, Charybdotoxin, Dehydration, Interleukin-8, Erythrocytes, Abnormal, Receptors, Cell Surface, Anemia, Sickle Cell, Intermediate-Conductance Calcium-Activated Potassium Channels, Oxygen, Potassium, Humans, Duffy Blood-Group System, Cell Shape, Chemokine CCL5
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