Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Copyright policy )Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
- University of Southampton United Kingdom
- QIMR Berghofer Medical Research Institute Australia
- University of Southern California United States
- Oxford Centre for Diabetes, Endocrinology and Metabolism United Kingdom
- Boston Children's Hospital United States
Central Nervous System, Medizin, Gene Dosage, 920106 Endocrine Organs and Diseases (excl. Diabetes), Body Mass Index, Cohort Studies, Coronary-artery-disease, ADULT OBESITY, Gene-expression, Anthropometry, COMMON VARIANTS, Single Nucleotide, 920103 Cardiovascular System and Diseases, CORONARY-ARTERY-DISEASE, CHILDHOOD OBESITY, Alcohol Dependence, EXPRESSION, 572, Quantitative Trait Loci, 610, body mass index, 970111 Expanding Knowledge in the Medical and Health Sciences, NEURITE OUTGROWTH, Polymorphism, Single Nucleotide, Quantitative Trait, C1, Quantitative Trait, Heritable, SDG 3 - Good Health and Well-being, Meta-Analysis as Topic, 616, Humans, Genetic Predisposition to Disease, Obesity, Polymorphism, GENOME-WIDE ASSOCIATION, FTO GENE, Heritable, Alleles, body weight regulation, ALCOHOL DEPENDENCE, Common variants, Body Weight, Genome-wide Association, MICE, 970106 Expanding Knowledge in the Biological Sciences, 060405 Gene Expression (incl. Microarray and other genome-wide approaches), Genome-Wide Association Study
Central Nervous System, Medizin, Gene Dosage, 920106 Endocrine Organs and Diseases (excl. Diabetes), Body Mass Index, Cohort Studies, Coronary-artery-disease, ADULT OBESITY, Gene-expression, Anthropometry, COMMON VARIANTS, Single Nucleotide, 920103 Cardiovascular System and Diseases, CORONARY-ARTERY-DISEASE, CHILDHOOD OBESITY, Alcohol Dependence, EXPRESSION, 572, Quantitative Trait Loci, 610, body mass index, 970111 Expanding Knowledge in the Medical and Health Sciences, NEURITE OUTGROWTH, Polymorphism, Single Nucleotide, Quantitative Trait, C1, Quantitative Trait, Heritable, SDG 3 - Good Health and Well-being, Meta-Analysis as Topic, 616, Humans, Genetic Predisposition to Disease, Obesity, Polymorphism, GENOME-WIDE ASSOCIATION, FTO GENE, Heritable, Alleles, body weight regulation, ALCOHOL DEPENDENCE, Common variants, Body Weight, Genome-wide Association, MICE, 970106 Expanding Knowledge in the Biological Sciences, 060405 Gene Expression (incl. Microarray and other genome-wide approaches), Genome-Wide Association Study
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