Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metastasis. In endometrioid carcinomas, the fascin expression profile is less defined, and the significance of CD44v6 is uncertain. We aimed to investigate the expressions of both fascin and CD44v6 in endometrioid carcinomas and to evaluate their inter-relation with clinicopathological parameters. Fascin and CD44v6 expressions were evaluated, individually and in combination, in a series of 47 endometrioid carcinomas and 10 proliferative endometrium samples. The staining extent and intensity of both markers in tumour cells were scored semiquantitatively. The relationship between immunoexpressions and clinicopathological variables was assessed. The expression rates of fascin and CD44v6 in endometrioid carcinoma were 72.34% and 46.80%, respectively. Although these expression rates were higher than those in proliferative endometrial samples, fascin expression showed a statistically significant difference from the normal group (p = 0.02), but CD44v6 did not differ (p = 0.54). Fascin expression was significantly correlated with tumour grade (p = 0.003) and neural invasion (p = 0.036) in a univariate analysis. In contrast, no significant correlation was found between CD44v6 and any of the clinicopathological parameters. Or findings suggest that fascin might be an independent prognostic indicator in the different steps of extracellular matrix invasion. On the other hand, CD44v6 was not a predictive factor in endometrioid cancer.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8511594927206899.

Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metatasis. Dans les carcinomes endométrioïdes, le profil d'expression fascinant est défini, et la signification de CD44v6 est uncertain. We aimed to investigate the expressions of both fascin and CD44v6 in endometrioid carcinomas and to evaluate their inter-relation with clinicopathological parameters.Fascin and CD44v6 expressions were evaluated, individualally and in combination, in a series of 47 endometrioid carcinomas and 10 proliferative endometrium samples. The staining extent and intensity of both markers in tumour cells were scored semiquantitatively. The relationship between immunoexpressions and clinicopathological variables was assessed.The expression rates of fascin and CD44v6 in endometrioid carcinoma were 72.34% and 46.80%, respectively. Although these expression rates were higher than those in proliferative endometrial samples, fascin expression showed a statistically significant difference from the normal group (p = 0.02), but CD44v6 did not differ (p = 0.54). Fascin expression was significantly correlated with tumour grade (p = 0,003) and neural invasion (p = 0,036) in a univariate analysis. En revanche, aucune corrélation significative n'a été trouvée entre CD44v6 et un des paramètres cliniques.Our findings suggest that fascin might be an independent pronostic indicator in the different steps of extracellular matrix invasion. On the other hand, CD44v6 was not a predictive factor in endometrioid cancer.The virtual slide(s) for this article can be found here : http://www.diagnosticpathology.diagnomx.eu/vs/8511594927206899.

Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metastasis. In endometrioid carcinomas, the fascin expression profile is less defined, and the significance of CD44v6 is uncertain. We aimed to investigate the expressions of both fascin and CD44v6 in endometrioid carcinomas and to evaluate their inter-relation with clinicopathological parameters.Fascin and CD44v6 expressions were evaluated, individually and in combination, in a series of 47 endometrioid carcinomas and 10 proliferative endometrium samples. The staining extent and intensity of both markers in tumour cells were scored semiquantitatively. The relationship between immunoexpressions and clinicopathological variables was assessed.The expression rates of fascin and CD44v6 in endometrioid carcinoma were 72.34% and 46.80%, respectively. Although these expression rates were higher than those in proliferative endometrial samples, fascin expression showed a statistically significant difference from the normal group (p = 0.02), but CD44v6 did not differ (p = 0.54). Fascin expression was significantly correlated with tumour grade (p = 0.003) and neural invasion (p = 0.036) in a univariate analysis. In contrast, no significant correlation was found between CD44v6 and any of the clinicopathological parameters.Our findings suggest that fascin might be an independent prognostic indicator in the different steps of extracellular matrix invasion. On the other hand, CD44v6 was not a predictive factor in endometrioid cancer.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8511594927206899.

Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metastasis. In endometrioid carcinomas, the fascin expression profile is less defined, and the significance of CD44v6 is uncertain. We aimed to investigate the expressions of both fascin and CD44v6 in endometrioid carcinomas and to evaluate their inter-relation with clinicopathological parameters.Fascin and CD44v6 expressions were evaluated, individually and in combination, in a series of 47 endometrioid carcinomas and 10 proliferative endometrium samples. The staining extent and intensity of both markers in tumour cells were scored semiquantitatively. The relationship between immunoexpressions and clinicopathological variables was assessed.The expression rates of fascin and CD44v6 in endometrioid carcinoma were 72.34% and 46.80%, respectively. Although these expression rates were higher than those in proliferative endometrial samples, fascin expression showed a statistically significant difference from the normal group (p = 0.02), but CD44v6 did not differ (p = 0.54). Fascin expression was significantly correlated with tumour grade (p = 0.003) and neural invasion (p = 0.036) in a univariate analysis. In contrast, no significant correlation was found between CD44v6 and any of the clinicopathological parameters.Our findings suggest that fascin might be an independent prognostic indicator in the different steps of extracellular matrix invasion. On the other hand, CD44v6 was not a predictive factor in endometrioid cancer.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8511594927206899.

قد يكون للفاسين و CD44v6 أدوار مهمة كمؤشرات حيوية في تطور الورم والانبثاث. في سرطانات بطانة الرحم، يكون ملف تعريف تعبير اللفافة أقل تحديدًا، وأهمية CD44v6 غير مؤكدة. كنا نهدف إلى التحقيق في تعبيرات كل من فاسين و CD44v6 في سرطانات بطانة الرحم وتقييم علاقتها المتبادلة مع المعلمات السريرية المرضية. تم تقييم تعبيرات فاسين و CD44v6، بشكل فردي وجماعي، في سلسلة من 47 سرطان بطانة الرحم و 10 عينات بطانة الرحم التكاثرية. تم تسجيل مدى تلطيخ وكثافة كلتا العلامتين في خلايا الورم بشكل شبه كمي. تم تقييم العلاقة بين التعبيرات المناعية والمتغيرات السريرية المرضية، وكانت معدلات التعبير عن الفاشين و CD44v6 في سرطان بطانة الرحم 72.34 ٪ و 46.80 ٪ على التوالي. على الرغم من أن معدلات التعبير هذه كانت أعلى من تلك الموجودة في عينات بطانة الرحم التكاثرية، إلا أن تعبير فاشين أظهر فرقًا ذا دلالة إحصائية عن المجموعة الطبيعية (p = 0.02)، لكن CD44v6 لم يختلف (p = 0.54). ارتبط تعبير الفاشين بشكل كبير بدرجة الورم (p = 0.003) والغزو العصبي (p = 0.036) في تحليل أحادي المتغير. في المقابل، لم يتم العثور على ارتباط كبير بين CD44v6 وأي من المعلمات السريرية المرضية. أو تشير النتائج إلى أن فاسين قد يكون مؤشرا إنذاريا مستقلا في الخطوات المختلفة لغزو المصفوفة خارج الخلية. من ناحية أخرى، لم يكن CD44v6 عاملاً تنبؤياً في سرطان بطانة الرحم. يمكن العثور على الشريحة(الشرائح) الافتراضية لهذه المقالة هنا: http://www.diagnosticpathology.diagnomx.eu/vs/8511594927206899.