A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
Copyright policy )A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM).A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q* = 0.15).First, a SNP in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pPROM (odds ratio, 2.12; 95% confidence interval, 1.47-3.07; P = .000068), and this association remained significant after correction for multiple comparisons. Second, haplotypes for Alpha 3 type IV collagen isoform precursor in the mother were associated with pPROM (global P = .003). Third, multilocus analysis identified a 3-locus model, which included maternal SNPs in collagen type I alpha 2, defensin alpha 5 gene, and endothelin 1.DNA variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pPROM.
- Pontifical Catholic University of Chile. Faculty of Arts Chile
- Pontifical Catholic University of Chile Chile
- Vanderbilt University United States
- National Institute of Health Pakistan
- Wayne State University United States
FACTOR-ALPHA GENE, Male, haplotype, Fetal Membranes, Premature Rupture, genotype, DNA variants, PREMATURE-RUPTURE, Autoantigens, INTERLEUKIN-1 RECEPTOR ANTAGONIST, Gene Frequency, 03 Salud y bienestar, TUMOR-NECROSIS-FACTOR, 05 Gender Equality, Endothelin-1, single-nucleotide polymorphism, chorioamnionitis, FALSE DISCOVERY RATE, Chorioamnionitis, genetic association study, Female, Collagen, 05 Igualdad de género, SINGLE NUCLEOTIDE POLYMORPHISM, Adult, Collagen Type IV, matrix metalloproteinase, Genotype, extracellular matrix, preterm prelabor rupture of membranes, THAN-G POLYMORPHISM, 610, Mothers, Collagen Type I, 618, Fetus, genomics, Humans, HUMAN UTERINE CERVIX, parturition, Genetic Association Studies, MIDTRIMESTER AMNIOTIC-FLUID, Models, Genetic, prematurity, Infant, Newborn, high dimensional biology, Haplotypes, Case-Control Studies, 03 Good Health and Well-being, EHLERS-DANLOS-SYNDROME
FACTOR-ALPHA GENE, Male, haplotype, Fetal Membranes, Premature Rupture, genotype, DNA variants, PREMATURE-RUPTURE, Autoantigens, INTERLEUKIN-1 RECEPTOR ANTAGONIST, Gene Frequency, 03 Salud y bienestar, TUMOR-NECROSIS-FACTOR, 05 Gender Equality, Endothelin-1, single-nucleotide polymorphism, chorioamnionitis, FALSE DISCOVERY RATE, Chorioamnionitis, genetic association study, Female, Collagen, 05 Igualdad de género, SINGLE NUCLEOTIDE POLYMORPHISM, Adult, Collagen Type IV, matrix metalloproteinase, Genotype, extracellular matrix, preterm prelabor rupture of membranes, THAN-G POLYMORPHISM, 610, Mothers, Collagen Type I, 618, Fetus, genomics, Humans, HUMAN UTERINE CERVIX, parturition, Genetic Association Studies, MIDTRIMESTER AMNIOTIC-FLUID, Models, Genetic, prematurity, Infant, Newborn, high dimensional biology, Haplotypes, Case-Control Studies, 03 Good Health and Well-being, EHLERS-DANLOS-SYNDROME
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