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Journal of Cell Science
Article . 2007 . Peer-reviewed
Data sources: Crossref
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The fatty acid elongase NOA is necessary for viability and has a somatic role inDrosophilasperm development

Authors: Martin Hollmann; Anita Jung; Mireille A. Schäfer;

The fatty acid elongase NOA is necessary for viability and has a somatic role inDrosophilasperm development

Abstract

The essential gene noa (CG 3971; also known as Baldspot) encodes a very long chain fatty acid elongase which is most similar to the mammalian elongase ELOVL6. noa is expressed in the nervous system from embryogenesis on, in imaginal discs, the fat body, malpighian tubules and in the gonads of both sexes. Its function is dose dependent, since reduced levels of noa RNA lead to impaired motility and severely reduced viability. In testes, noa RNA is detected in the cyst cells during the postmeiotic phase of germ cell development. An RNAi construct selectively driven in cyst cells leads to male sterility, demonstrating the necessity of noa function for male germline development and the interaction of the somatic cyst cells with the developing sperm.

Related Organizations
Keywords

Male, Embryo, Nonmammalian, Cell Survival, Fatty Acid Elongases, Gene Expression Profiling, Molecular Sequence Data, Genes, Insect, Cell Communication, Gene Expression Regulation, Enzymologic, Drosophila melanogaster, Enhancer Elements, Genetic, Acetyltransferases, Organ Specificity, Mutation, DNA Transposable Elements, Animals, Amino Acid Sequence, RNA, Messenger, 5' Untranslated Regions, 3' Untranslated Regions

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    47
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
47
Top 10%
Top 10%
Average
bronze