Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells
Copyright policy )Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells
Integrin-mediated adhesion is essential for the formation of stable contacts between T cells and antigen-presenting cells (APCs). We show that Vav1 controls integrin-mediated adhesion of thymocytes and T cells to ECM proteins and ICAM1 following TCR stimulation. In a peptide-specific system, Vav1 is required for T cell adhesion to peptide-loaded APCs. Intriguingly, TCR-induced cell adhesion and aggregation of integrins occurs independent of WASP. Whereas LFA-1 and actin caps colocalize in wasp(-/-) T cells in response to TCR stimulation, loss of WASP uncouples TCR caps from actin patches. Our data reveal a novel role for Vav1 and WASP in the regulation of TCR-induced integrin clustering and cell adhesion and show that integrin and TCR clustering are controlled by distinct pathways.
- University of Toronto Canada
- Austrian Academy of Sciences Austria
- Amgen (United States) United States
- Howard Hughes Medical Institute United States
- Amgen (Canada) Canada
Mice, Knockout, Antigen Presentation, Integrins, Immunology, Lymphocyte Cooperation, Receptors, Antigen, T-Cell, Proteins, Cell Cycle Proteins, Major Histocompatibility Complex, Mice, Infectious Diseases, Proto-Oncogene Proteins, Cell Adhesion, Immunology and Allergy, Animals, Proto-Oncogene Proteins c-vav, Wiskott-Aldrich Syndrome Protein
Mice, Knockout, Antigen Presentation, Integrins, Immunology, Lymphocyte Cooperation, Receptors, Antigen, T-Cell, Proteins, Cell Cycle Proteins, Major Histocompatibility Complex, Mice, Infectious Diseases, Proto-Oncogene Proteins, Cell Adhesion, Immunology and Allergy, Animals, Proto-Oncogene Proteins c-vav, Wiskott-Aldrich Syndrome Protein
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