Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease
Copyright policy )Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease
Several genes have been related to late-onset Alzheimer's disease (LOAD). Phospholipases A2 (PLA2) influence the processing and secretion of the amyloid precursor protein, which gives rise to the beta-amyloid peptide, the major component of the amyloid plaque in AD. Hence, in the present study, polymorphisms of three genes encoding PLA2 enzymes group (cytosolic PLA2: BanI cPLA2 polymorphism; calcium-independent PLA2: AvrII iPLA2 polymorphism; PAFAH: Val279Phe PAFAH polymorphism) were analysed in a case-control sample using 58 patients with LOAD and 107 matched healthy controls. There was a genotypic association between the BanI cPLA2 polymorphism and LOAD (χ2=6.25, 2df, p=0.04), however there was no allelic association. There were no associations between AvrII iPLA2 and Val279Phe PAFAH polymorphisms and LOAD. These data suggest that the BanI cPLA2 polymorphism may play a role in the susceptibility for LOAD in our Brazilian sample.
- Universidade de São Paulo Brazil
- UNIVERSIDADE DE SAO PAULO Brazil
Male, PLA2, Polymorphism, Genetic, Genotype, demência, Phospholipases A2, Cytosolic, genética, Alzheimer de início tardio, Alzheimer Disease, Case-Control Studies, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Phospholipases A2, Calcium-Independent, Humans, genetics, Female, Genetic Predisposition to Disease, LOAD, gene, Alleles, dementia, Aged
Male, PLA2, Polymorphism, Genetic, Genotype, demência, Phospholipases A2, Cytosolic, genética, Alzheimer de início tardio, Alzheimer Disease, Case-Control Studies, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Phospholipases A2, Calcium-Independent, Humans, genetics, Female, Genetic Predisposition to Disease, LOAD, gene, Alleles, dementia, Aged
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