Non-Homologous DNA End Joining in Anticancer Therapy
Copyright policy ) Elzbieta, Pastwa; Mariusz, Malinowski;
Non-Homologous DNA End Joining in Anticancer Therapy
Non-homologous DNA end joining (NHEJ) is the major pathway for the repair of double-strand breaks (DSBs) in human cells. Proteins involved in NHEJ pathway can become molecular targets in the treatment of cancer. Inhibition of this pathway leads to radio- and chemosensitization of cancer cells. This review will focus on the new therapeutic strategies for NHEJ pathway inhibition and their application in anticancer therapy.
- Medical University of Lodz Poland
DNA-Binding Proteins, DNA Repair Enzymes, DNA Repair, Neoplasms, Animals, Humans, Antineoplastic Agents, DNA Breaks, Double-Stranded
DNA-Binding Proteins, DNA Repair Enzymes, DNA Repair, Neoplasms, Animals, Humans, Antineoplastic Agents, DNA Breaks, Double-Stranded
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 7
Average
Average
Top 10%
