Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia
Copyright policy )Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia
The presence of an altered Hox-2.4 gene in the WEHI3B murine myeloid leukemia suggests that homeobox genes may contribute to neoplasia. A survey of 31 leukemia cell lines of the myeloid, lymphoid and erythroid lineages revealed that Hox-2.4 was expressed only in WEHI3B and the pre-B lymphoid line 70Z/3, in which no DNA rearrangement was observed. To clarify the WEHI3B alteration and normal Hox-2.4 structure, we have sequenced near full length cDNA clones from WEHI3B and 70Z/3, and the 5' portion of the normal Hox-2.4 gene. A WEHI3B cDNA clone demonstrates that an intracisternal A-particle (IAP) provirus has inserted within the first exon of the gene and generated a Hox-2.4 mRNA with a 5' sequence derived from the IAP long terminal repeat. A remarkable degree of similarity found between the amino acid sequences of Hox-2.4 and Hox-3.1, which reside on different chromosomes, supports the notion that an ancient homeobox gene cluster has been duplicated and dispersed early in vertebrate evolution.
Mice, Inbred BALB C, Base Sequence, Molecular Sequence Data, Genes, Homeobox, Hematopoietic Stem Cells, Cell Line, Mice, Viral Proteins, Genes, Intracisternal A-Particle, Gene Expression Regulation, Leukemia, Myeloid, Sequence Homology, Nucleic Acid, Animals, Amino Acid Sequence, RNA, Messenger
Mice, Inbred BALB C, Base Sequence, Molecular Sequence Data, Genes, Homeobox, Hematopoietic Stem Cells, Cell Line, Mice, Viral Proteins, Genes, Intracisternal A-Particle, Gene Expression Regulation, Leukemia, Myeloid, Sequence Homology, Nucleic Acid, Animals, Amino Acid Sequence, RNA, Messenger
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