Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
Copyright policy )Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
The adaptors SAP, EAT-2 and ERT are specific to cells of the immune system and belong to the SAP family. All three are expressed in natural killer (NK) cells. Here we examined the global function of the SAP family using mice lacking SAP, EAT-2 and ERT. These adaptors acted together in a mechanism that was essential for the elimination of hematopoietic but not nonhematopoietic cells by NK cells. This function was mediated by many receptors of the SLAM family on NK cells that were engaged by ligands found solely on hematopoietic cells. In the absence of SAP-related adaptors, SLAM receptors lost their activating function and became inhibitory receptors that repressed other activating receptors, such as NKG2D. Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells.
- Inserm France
- French Institute of Health and Medical Research France
- Montreal Clinical Research Institute Canada
- Necker-Enfants Malades Hospital France
- McGill University Canada
Mice, Knockout, Hematopoietic System, Histocompatibility Antigens Class I, Intracellular Signaling Peptides and Proteins, CHO Cells, CD48 Antigen, Lymphocyte Activation, Rats, Killer Cells, Natural, Mice, Inbred C57BL, Interferon-gamma, Mice, Cricetulus, Antigens, CD, NK Cell Lectin-Like Receptor Subfamily K, Cricetinae, Animals, Antigens, Ly, Signaling Lymphocytic Activation Molecule Associated Protein, Adaptor Proteins, Signal Transducing
Mice, Knockout, Hematopoietic System, Histocompatibility Antigens Class I, Intracellular Signaling Peptides and Proteins, CHO Cells, CD48 Antigen, Lymphocyte Activation, Rats, Killer Cells, Natural, Mice, Inbred C57BL, Interferon-gamma, Mice, Cricetulus, Antigens, CD, NK Cell Lectin-Like Receptor Subfamily K, Cricetinae, Animals, Antigens, Ly, Signaling Lymphocytic Activation Molecule Associated Protein, Adaptor Proteins, Signal Transducing
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