Human Chromosome 7: DNA Sequence and Biology
Copyright policy )Human Chromosome 7: DNA Sequence and Biology
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
- University of Toronto Canada
- University of British Columbia Canada
- University of Hong Kong China (People's Republic of)
- Yale University United States
- Harvard University United States
Williams Syndrome, Expressed Sequence Tag, Euchromatin, Congenital, Mice, Complementary, Neoplasms, Gene Duplication, Databases, Genetic, Genes, Overlapping, In Situ Hybridization, In Situ Hybridization, Fluorescence, Overlapping, Expressed Sequence Tags, Research Support, Non-U.S. Gov't, Chromosome Fragile Sites, Sequence analysis, Chromosome Mapping, Congenital Abnormalitie, Limb Deformities, Expressed sequence tags, Genetic Diseases, Pair 7, Animals; Autistic Disorder; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mapping; Chromosomes, Human, Pair 7; Computational Biology; Congenital Abnormalities; CpG Islands; DNA, Complementary; Databases, Genetic; Euchromatin; Expressed Sequence Tags; Gene Duplication; Genes, Overlapping; Genetic Diseases, Inborn; Genomic Imprinting; Humans; In Situ Hybridization, Fluorescence; Limb Deformities, Congenital; Mice; Molecular Sequence Data; Mutation; Neoplasms; Pseudogenes; RNA; Retroelements; Williams Syndrome; Sequence Analysis, DNA, Dna, complementary, Sequence Analysis, Pseudogenes, Chromosomes, Human, Pair 7, Human, Genetic diseases, DNA, Complementary, inborn - genetics, Retroelements, Genetic diseases, inborn - genetics, Molecular Sequence Data, Limb Deformities, Congenital, Chromosome Aberration, Sequence analysis, dna, Fluorescence, Chromosomes, Congenital Abnormalities, Databases, Pseudogene, Genomic Imprinting, Genetic, complementary, Journal Article, Animals, Humans, human, Autistic Disorder, Chromosome Aberrations, Animal, Chromosome Fragility, Genetic Diseases, Inborn, Computational Biology, DNA, Dna, Sequence Analysis, DNA, Settore MED/15 - MALATTIE DEL SANGUE, Inborn, Genes, Mutation, Animals; Humans; In Situ Hybridization, Fluorescence; Chromosome Mapping; Genomic Imprinting; Limb Deformities, Congenital; DNA, Complementary; Williams Syndrome; Autistic Disorder; Chromosome Fragility; Molecular Sequence Data; Databases, Genetic; Congenital Abnormalities; Pseudogenes; Euchromatin; Gene Duplication; Genes, Overlapping; Mice; Computational Biology; Sequence Analysis, DNA; Retroelements; Chromosomes, Human, Pair 7; Neoplasms; RNA; Genetic Diseases, Inborn; CpG Islands; Chromosome Fragile Sites; Chromosome Aberrations; Expressed Sequence Tags; Mutation, Neoplasm, RNA, CpG Islands, pair 7 - genetics, Chromosome Fragile Site, CpG Island, Chromosomes, human, pair 7 - genetics, Retroelement
Williams Syndrome, Expressed Sequence Tag, Euchromatin, Congenital, Mice, Complementary, Neoplasms, Gene Duplication, Databases, Genetic, Genes, Overlapping, In Situ Hybridization, In Situ Hybridization, Fluorescence, Overlapping, Expressed Sequence Tags, Research Support, Non-U.S. Gov't, Chromosome Fragile Sites, Sequence analysis, Chromosome Mapping, Congenital Abnormalitie, Limb Deformities, Expressed sequence tags, Genetic Diseases, Pair 7, Animals; Autistic Disorder; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mapping; Chromosomes, Human, Pair 7; Computational Biology; Congenital Abnormalities; CpG Islands; DNA, Complementary; Databases, Genetic; Euchromatin; Expressed Sequence Tags; Gene Duplication; Genes, Overlapping; Genetic Diseases, Inborn; Genomic Imprinting; Humans; In Situ Hybridization, Fluorescence; Limb Deformities, Congenital; Mice; Molecular Sequence Data; Mutation; Neoplasms; Pseudogenes; RNA; Retroelements; Williams Syndrome; Sequence Analysis, DNA, Dna, complementary, Sequence Analysis, Pseudogenes, Chromosomes, Human, Pair 7, Human, Genetic diseases, DNA, Complementary, inborn - genetics, Retroelements, Genetic diseases, inborn - genetics, Molecular Sequence Data, Limb Deformities, Congenital, Chromosome Aberration, Sequence analysis, dna, Fluorescence, Chromosomes, Congenital Abnormalities, Databases, Pseudogene, Genomic Imprinting, Genetic, complementary, Journal Article, Animals, Humans, human, Autistic Disorder, Chromosome Aberrations, Animal, Chromosome Fragility, Genetic Diseases, Inborn, Computational Biology, DNA, Dna, Sequence Analysis, DNA, Settore MED/15 - MALATTIE DEL SANGUE, Inborn, Genes, Mutation, Animals; Humans; In Situ Hybridization, Fluorescence; Chromosome Mapping; Genomic Imprinting; Limb Deformities, Congenital; DNA, Complementary; Williams Syndrome; Autistic Disorder; Chromosome Fragility; Molecular Sequence Data; Databases, Genetic; Congenital Abnormalities; Pseudogenes; Euchromatin; Gene Duplication; Genes, Overlapping; Mice; Computational Biology; Sequence Analysis, DNA; Retroelements; Chromosomes, Human, Pair 7; Neoplasms; RNA; Genetic Diseases, Inborn; CpG Islands; Chromosome Fragile Sites; Chromosome Aberrations; Expressed Sequence Tags; Mutation, Neoplasm, RNA, CpG Islands, pair 7 - genetics, Chromosome Fragile Site, CpG Island, Chromosomes, human, pair 7 - genetics, Retroelement
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