Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities
Copyright policy )Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities
Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of "coronavirus disease 2019", abbreviated to COVID-19, which despite only being identified at the very end of 2019, has now been classified as a pandemic by the World Health Organization (WHO). At this time, no specific prophylactic or postexposure therapy for COVID-19 are currently available. Viral entry is the first step in the SARS-CoV-2 lifecycle and is mediated by the trimeric spike protein. Being the first stage in infection, entry of SARS-CoV-2 into host cells is an extremely attractive therapeutic intervention point. Within this review, we highlight therapeutic intervention strategies for anti-SARS-CoV, MERS-CoV, and other coronaviruses and speculate upon future directions for SARS-CoV-2 entry inhibitor designs.
- University of California, San Diego United States
- Shandong University
- ISLAMIC AZAD UNIVERSITY Iran (Islamic Republic of)
- Drexel University United States
- Islamic Azad University Janah Iran (Islamic Republic of)
SARS-CoV-2, Cathepsin L, COVID-19, Angiotensin-Converting Enzyme Inhibitors, Virus Internalization, Antiviral Agents, Cell Line, COVID-19 Drug Treatment, Protein Domains, Drug Discovery, Spike Glycoprotein, Coronavirus, Molecular Medicine, Animals, Humans, Amino Acid Sequence, Angiotensin-Converting Enzyme 2
SARS-CoV-2, Cathepsin L, COVID-19, Angiotensin-Converting Enzyme Inhibitors, Virus Internalization, Antiviral Agents, Cell Line, COVID-19 Drug Treatment, Protein Domains, Drug Discovery, Spike Glycoprotein, Coronavirus, Molecular Medicine, Animals, Humans, Amino Acid Sequence, Angiotensin-Converting Enzyme 2
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