Mapping of theKHSRPGene to a Region of Conserved Synteny on Human Chromosome 19p13.3 and Mouse Chromosome 17
Copyright policy )Mapping of theKHSRPGene to a Region of Conserved Synteny on Human Chromosome 19p13.3 and Mouse Chromosome 17
The K homology-type splicing regulatory protein, KSRP, activates splicing through intronic splicing enhancer sequences. It is highly expressed in neural cells and is required for the neural-specific splicing of the c-src N1 exon. In this study, we mapped the gene (gene symbols KHSRP and Khsrp) to human chromosome 19 by using radiation hybrid panels and to mouse chromosome 17 by studying an interspecific backcross panel. Human KHSRP is a positional candidate gene for familial febrile convulsion and Cayman type cerebellar ataxia. Comparative analysis of the human and mouse genomes indicates that the KHSRP gene is located in regions of conserved synteny between the two species.
- Stanford University United States
- University of California, Los Angeles United States
- Howard Hughes Medical Institute United States
Genetic Markers, Databases, Factual, Models, Genetic, Chromosome Mapping, RNA-Binding Proteins, Polymerase Chain Reaction, Alternative Splicing, Mice, Trans-Activators, Animals, Humans, Chromosomes, Human, Pair 19, Conserved Sequence, Polymorphism, Single-Stranded Conformational
Genetic Markers, Databases, Factual, Models, Genetic, Chromosome Mapping, RNA-Binding Proteins, Polymerase Chain Reaction, Alternative Splicing, Mice, Trans-Activators, Animals, Humans, Chromosomes, Human, Pair 19, Conserved Sequence, Polymorphism, Single-Stranded Conformational
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!