A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Copyright policy )A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.
- Harvard University United States
- Brigham and Women's Faulkner Hospital United States
- Dana Farber Cancer Institute Harvard Medical School United States
- Harvard Medical School
- Harvard Medical School Finland
medicine, Cells, Adipose Tissue, White, Cell Respiration, Subcutaneous Fat, 610, White, Mice, Transgenic, medical research, Transgenic, Ion Channels, Mitochondrial Proteins, Plasma, Mice, Conditioned, Adipose Tissue, Brown, Models, Physical Conditioning, Animal, cell biology, Adipocytes, biochemistry, Animals, Humans, Obesity, Exercise, Inbred BALB C, Cells, Cultured, Muscle Cells, Mice, Inbred BALB C, Cultured, Animal, Intracellular Signaling Peptides and Proteins, Brown, health, Thermogenesis, Physical Conditioning, Hormones, Culture Media, Adipose Tissue, Gene Expression Regulation, Culture Media, Conditioned, Models, Animal, Trans-Activators, Insulin Resistance, Energy Metabolism
medicine, Cells, Adipose Tissue, White, Cell Respiration, Subcutaneous Fat, 610, White, Mice, Transgenic, medical research, Transgenic, Ion Channels, Mitochondrial Proteins, Plasma, Mice, Conditioned, Adipose Tissue, Brown, Models, Physical Conditioning, Animal, cell biology, Adipocytes, biochemistry, Animals, Humans, Obesity, Exercise, Inbred BALB C, Cells, Cultured, Muscle Cells, Mice, Inbred BALB C, Cultured, Animal, Intracellular Signaling Peptides and Proteins, Brown, health, Thermogenesis, Physical Conditioning, Hormones, Culture Media, Adipose Tissue, Gene Expression Regulation, Culture Media, Conditioned, Models, Animal, Trans-Activators, Insulin Resistance, Energy Metabolism
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