New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.
Copyright policy )New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.
Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).
- Keio University Japan
Meclofenamic Acid, Plants, Medicinal, Estradiol, Molecular Structure, Plant Extracts, Plant Components, Aerial, Acetone, Leonurus, Liver, Solvents, Animals, Humans, Diterpenes, Enzyme Inhibitors, Sulfotransferases, Phytotherapy
Meclofenamic Acid, Plants, Medicinal, Estradiol, Molecular Structure, Plant Extracts, Plant Components, Aerial, Acetone, Leonurus, Liver, Solvents, Animals, Humans, Diterpenes, Enzyme Inhibitors, Sulfotransferases, Phytotherapy
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).30 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!