Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke–Blackburn–Bienaymé reaction and their Hsp90 inhibitory activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2015 English Publisher:Royal Society of Chemistry (RSC)Journal:Organic & Biomolecular Chemistry, volume 13, pages 1,531-1,535 (issn: 1477-0520, eissn: 1477-0539,

Authors: Jing, Ren; Min, Yang; Hongchun, Liu; Danyan, Cao; Danqi, Chen; Jian, Li; Le, Tang; +5 Authors

doi: 10.1039/c4ob01865f

pmid: 25490978

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke–Blackburn–Bienaymé reaction and their Hsp90 inhibitory activity

- Summary
- Subjects
- Related research
  (11)
- Metrics

tips_and_updates
Recommended

Abstract

Various 3,8-diaminoimidazo[1,2-a]pyrazines were efficiently prepared by MCR and some products showed moderate Hsp90 inhibitory activity.

Related Organizations

Shanghai Institute of Materia Medica
China (People's Republic of)
Shanghai Institute of Applied Physics
China (People's Republic of)
Chinese Academy of Sciences
China (People's Republic of)

Keywords

Models, Molecular, Protein Conformation, Drug Design, Pyrazines, HSP90 Heat-Shock Proteins

11 Research products, page 1 of 2

Microwave-Assisted Synthesis of Bis-Heterocycles Containing the Imidazo[1,2-a]Pyridine by Groebke-Blackburn-Bienaymé Reaction
2019IsAmongTopNSimilarDocuments
First biocatalytic Groebke-Blackburn-Bienaymé reaction to synthesize imidazo[1,2-a]pyridine derivatives using lipase enzyme
2020IsAmongTopNSimilarDocuments
Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke–Blackburn–Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria
2022IsAmongTopNSimilarDocuments
Fast Assembly of 1H-Imidazo[1,2-a]imidazol-5-amines via Groebke-Blackburn-Bienaymé Reaction with 2-Aminoimidazoles
2013IsAmongTopNSimilarDocuments
Crystal structure of human hsp90 with jr9
2014IsRelatedTo
Crystal structure of human hsp90 with jr9
2014IsSupplementTo
A Comparative Study on the Groebke-Blackburn-Bienaymé Three-Component Reaction Catalyzed by Rare Earth Triflates under Microwave Heating
2020IsAmongTopNSimilarDocuments
A Comparative Study on the Groebke-Blackburn-Bienaymé Three-Component Reaction Catalyzed by Rare Earth Triflates under Microwave Heating
2021IsAmongTopNSimilarDocuments
Heat shock protein HSP 90-alpha
2017IsRelatedTo
Diversity-Oriented Synthesis of Imidazo-Dipyridines with Anticancer Activity via the Groebke–Blackburn–Bienaymé and TBAB-Mediated Cascade Reaction in One Pot
2019IsAmongTopNSimilarDocuments

chevron_left
1
2
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	19
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%