A 2.7-kb Deletion in the Human NLRP10 Gene Exon 2 Occurred After the Human–Chimpanzee Divergence
Copyright policy )A 2.7-kb Deletion in the Human NLRP10 Gene Exon 2 Occurred After the Human–Chimpanzee Divergence
NLRP10 is a member of the NLRP protein family, which is involved in inflammation and apoptosis. Genome sequence comparisons revealed that a 2.7-kb deletion occurred in the human NLRP10 gene exon 2 after the divergence of humans and chimpanzees, resulting in replacement of the entire 3' untranslated region with the flanking LINE-1 element. The human NLRP10 protein lost 30 or more amino acids that are conserved in primates at its carboxy-terminus. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution.
- Chung-Ang University Korea (Republic of)
Base Sequence, Pan troglodytes, Molecular Sequence Data, Exons, Evolution, Molecular, Species Specificity, Animals, Humans, Amino Acid Sequence, Apoptosis Regulatory Proteins, Carrier Proteins, Sequence Alignment, Gene Deletion, Adaptor Proteins, Signal Transducing
Base Sequence, Pan troglodytes, Molecular Sequence Data, Exons, Evolution, Molecular, Species Specificity, Animals, Humans, Amino Acid Sequence, Apoptosis Regulatory Proteins, Carrier Proteins, Sequence Alignment, Gene Deletion, Adaptor Proteins, Signal Transducing
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