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The Polycomb complex PRC2 and its mark in life

descriptionPublicationkeyboard_double_arrow_right Article 19 Jan 2011 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 469, pages 343-349 (issn: 0028-0836, eissn: 1476-4687,

Authors: Danny Reinberg; Raphaël Margueron;

doi: 10.1038/nature09784

pmid: 21248841

pmc: PMC3760771

The Polycomb complex PRC2 and its mark in life

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Abstract

Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

Related Organizations

New York University
United States
University of Chicago
United States
Institute Curie
France
Howard Hughes Medical Institute
United States

Keywords

Genome, Polycomb-Group Proteins, Cell Differentiation, Histone-Lysine N-Methyltransferase, Methylation, Chromatin, Evolution, Molecular, Histones, Repressor Proteins, Neoplasms, Animals, Humans

18 Research products, page 1 of 2

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Jing, isoform I
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Polycomb protein Su(z)12
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Histone-lysine N-methyltransferase E(z)
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1.28 protein
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Polycomb protein esc
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Probable histone-binding protein Caf1
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LD17709p
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Enhancer of zeste, isoform C
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Polycomblike, isoform B
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