Cyclops‐independent floor plate differentiation in zebrafish embryos
Copyright policy )Cyclops‐independent floor plate differentiation in zebrafish embryos
AbstractIn zebrafish, development of the ventral neural tube depends on the Nodal‐related signal Cyclops (Cyc). One‐day‐old cyc mutant embryos lack the medial floor plate (MFP). We show here that cells expressing MFP marker genes differentiate gradually in cyc mutant embryos in a delayed manner during the second day of development. This late differentiation is restricted to the hindbrain and spinal cord and depends on an intact Hedgehog (Hh) signalling pathway. Cells expressing MFP marker genes in cyc mutant embryos appear to be derived from lateral floor plate (LFP) cells as they coexpress LFP and MFP marker genes. This finding suggests that the correct temporal development of the MFP is required for the distinction of LFP and MFP cells in wild‐type embryos. © 2002 Wiley‐Liss, Inc.
570, Embryo, Nonmammalian, Time Factors, Transfection, Transforming Growth Factor beta, Animals, Transgenes, Alleles, Zebrafish, info:eu-repo/classification/ddc/570, Microscopy, Video, biology, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Cell Differentiation, Zebrafish Proteins, Life sciences, Rhombencephalon, Spinal Cord, Neural Crest, Mutation, ddc:570, Signal Transduction
570, Embryo, Nonmammalian, Time Factors, Transfection, Transforming Growth Factor beta, Animals, Transgenes, Alleles, Zebrafish, info:eu-repo/classification/ddc/570, Microscopy, Video, biology, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Cell Differentiation, Zebrafish Proteins, Life sciences, Rhombencephalon, Spinal Cord, Neural Crest, Mutation, ddc:570, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).19 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!