IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites
Copyright policy )IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites. Memory CD8+ T cells lacking the IL-4R are unable to establish a stable population residing in nonlymphoid organs, although they develop normally in lymphoid organs. Because memory cells from nonlymphoid organs disappear shortly after immunization, the protective antiparasitic activity of this T cell response also is lost. These results demonstrate that IL-4/IL-4R interactions on CD8+ T cells play a critical role in modulating the development and tissue distribution of memory cells induced by parasite immunization. They also indicate that memory cells residing in nonlymphoid tissues are critical for protective immunity against malaria parasites.
- Johns Hopkins University United States
- JOHNS HOPKINS UNIVERSITY
- Johns Hopkins University United States
- Indian Council of Medical Research India
- National Institute of Malaria Research India
Immunity, Cellular, Mice, Inbred BALB C, Vaccination, Protozoan Proteins, Cell Differentiation, Mice, Transgenic, Plasmodium yoelii, CD8-Positive T-Lymphocytes, Article, Malaria, Receptors, Interleukin-4, Mice, Malaria Vaccines, Animals, Interleukin-4, Immunologic Memory
Immunity, Cellular, Mice, Inbred BALB C, Vaccination, Protozoan Proteins, Cell Differentiation, Mice, Transgenic, Plasmodium yoelii, CD8-Positive T-Lymphocytes, Article, Malaria, Receptors, Interleukin-4, Mice, Malaria Vaccines, Animals, Interleukin-4, Immunologic Memory
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).70 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!