Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
Copyright policy )Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
MicroRNAs are short single‑stranded non‑coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade Ⅳ glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma from the Chinese Glioma Genome Atlas data set, it was observed that microRNA‑206 (miR‑206) was downregulated in high-grade (grades Ⅲ and Ⅳ) gliomas compared with grade II gliomas. In addition, high expression of miR‑206 was associated with longer overall survival time in glioma patients. The present study aimed to investigate the biological functions of miR‑206 in glioma progression in vitro using the LN229 glioma cell line. Cell proliferation was observed to be inhibited subsequent to transfection with miR‑206. It was suggested that miR‑206 induced cell cycle G1/S phase arrest by suppressing the expression of cyclinD2. The results of the present study concluded that miR‑206 inhibits glioma progression via the regulation of cyclinD2 and that miR‑206 may be a novel biomarker with potential for use as a therapeutic target in gliomas.
- Capital Medical University China (People's Republic of)
Binding Sites, Base Sequence, Articles, Cell Cycle Checkpoints, Glioma, Prognosis, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Line, Tumor, Cyclin D2, Humans, RNA Interference, RNA, Messenger, Neoplasm Grading, Cell Proliferation
Binding Sites, Base Sequence, Articles, Cell Cycle Checkpoints, Glioma, Prognosis, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Line, Tumor, Cyclin D2, Humans, RNA Interference, RNA, Messenger, Neoplasm Grading, Cell Proliferation
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