Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1
Copyright policy )Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1
ABSTRACT Proximal-distal leg development in Drosophila involves a battery of genes expressed and required in specific proximal-distal (PD) domains of the appendage. Here we report the characterisation of a new gene of this type, dlim1, a member of the Lhx family of genes whose proteins contain two Lim domains and a homeodomain. We show that the Lhx gene apterous (ap) is also required for PD leg development, and we study the functional interactions between ap, dlim1 and other PD genes during leg development. Our results show that a regulatory network formed by ap and dlim1 plus the homeobox genes aristaless and Bar specifies distal leg cell fates in Drosophila.
- Royal Holloway University of London United Kingdom
- University of London United Kingdom
Homeodomain Proteins, Male, DNA, Complementary, Base Sequence, LIM-Homeodomain Proteins, Molecular Sequence Data, Genes, Homeobox, Gene Expression Regulation, Developmental, Extremities, Genes, Insect, Enhancer Elements, Genetic, Mutation, Animals, Drosophila Proteins, Drosophila, Female, Amino Acid Sequence, In Situ Hybridization, Body Patterning, DNA Primers
Homeodomain Proteins, Male, DNA, Complementary, Base Sequence, LIM-Homeodomain Proteins, Molecular Sequence Data, Genes, Homeobox, Gene Expression Regulation, Developmental, Extremities, Genes, Insect, Enhancer Elements, Genetic, Mutation, Animals, Drosophila Proteins, Drosophila, Female, Amino Acid Sequence, In Situ Hybridization, Body Patterning, DNA Primers
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