Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome
Copyright policy )Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome
L1 is a glycoprotein with an apparent molecular weight of 200 kDa in the developing fetus and adult central nervous system. In the peripheral nervous system, it has a molecular weight of 230 kDa. The L1 protein appears to be encoded by a single gene that has been located on the human X chromosome by in situ hybridization. In this paper we describe restriction variation in genomic DNA Southern analysis between Mus species for the K13 cDNA probe for the L1 neural cell adhesion molecule. We have designated the locus described by this variation as cell adhesion molecule L1, CamL1. The X chromosome linkage and the relative position on the X chromosome coincident with the genes Rsvp/G6pd/Cf-8 were defined in backcross matings involving M. spretus and M. musculus.
- Heidelberg University Germany
- Roswell Park Cancer Institute United States
Male, X Chromosome, Genetic Linkage, Cell Adhesion Molecules, Neuronal, Chromosome Mapping, DNA Restriction Enzymes, Mice, Inbred C57BL, Muridae, Blotting, Southern, Mice, Animals, Female, Leukocyte L1 Antigen Complex, Crosses, Genetic
Male, X Chromosome, Genetic Linkage, Cell Adhesion Molecules, Neuronal, Chromosome Mapping, DNA Restriction Enzymes, Mice, Inbred C57BL, Muridae, Blotting, Southern, Mice, Animals, Female, Leukocyte L1 Antigen Complex, Crosses, Genetic
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