Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer
Copyright policy )Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer
Significance All cancer lesions sustain alterations in signaling pathways, which are the drivers of disease initiation and progression. Study of altered signaling in cancer is thus important to develop more effective therapeutic regimens as well as better prognostic markers. In this study, we show that two of the most frequently altered signaling pathways in prostate cancer, the androgen receptor and the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways, are dependent on kallikrein related peptidase 4 (KLK4), whose expression is highly prostate enriched. Our results suggest that KLK4 has a central role in prostate cancer survival and that KLK4 silencing may have significant therapeutic efficacy.
- University of Oslo Norway
- The University of Texas MD Anderson Cancer Center United States
- Portuguese Oncology Institute Portugal
- The University of Texas System United States
- Universidade Lusófona do Porto Portugal
Male, Cell Death, Ribosomal Protein S6 Kinases, TOR Serine-Threonine Kinases, G1 Phase, Prostatic Neoplasms, Enzyme Activation, Receptors, Androgen, Gene Knockdown Techniques, Androgens, Humans, Kallikreins, Cell Division, Signal Transduction
Male, Cell Death, Ribosomal Protein S6 Kinases, TOR Serine-Threonine Kinases, G1 Phase, Prostatic Neoplasms, Enzyme Activation, Receptors, Androgen, Gene Knockdown Techniques, Androgens, Humans, Kallikreins, Cell Division, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).59 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!