Association of HLA-A in autoimmune myasthenia gravis with thymoma
Copyright policy )Association of HLA-A in autoimmune myasthenia gravis with thymoma
We investigated an association of the HLA-A locus in 78 French Caucasian patients with autoimmune myasthenia gravis (MG) and thymic epithelial tumours. The largest effect was a protection associated with HLA-A02 in MG patients with a B2 type thymoma (OR=0.323, 95% CI: 0.113-0.756, P=0.00041). The frequency of HLA-A25 was also increased in the whole group of patients (OR=3.62, 95% CI: 1.62-7.08, P=0.0041). Our findings emphasise the interest of the histological classification in the genetic study of thymomas.
Adult, Genetic Markers, Male, Heterozygote, Genotype, HLA-A Antigens, Thymoma, Histocompatibility Testing, DNA Mutational Analysis, Thymus Gland, White People, Genetics, Population, Gene Frequency, Myasthenia Gravis, Humans, Female, Genetic Predisposition to Disease, France, Genetic Testing, Autoantibodies
Adult, Genetic Markers, Male, Heterozygote, Genotype, HLA-A Antigens, Thymoma, Histocompatibility Testing, DNA Mutational Analysis, Thymus Gland, White People, Genetics, Population, Gene Frequency, Myasthenia Gravis, Humans, Female, Genetic Predisposition to Disease, France, Genetic Testing, Autoantibodies
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