Crucial roles of Brn1 in distal tubule formation and function in mouse kidney
Copyright policy )Crucial roles of Brn1 in distal tubule formation and function in mouse kidney
This study identifies a role for the gene for the POU transcription factor Brn1 in distal tubule formation and function in the mammalian kidney. Normal development of Henle's loop (HL), the distal convoluted tubule and the macula densa was severely retarded in Brn1-deficient mice. In particular,elongation and differentiation of the developing HL was affected. In the adult kidney, Brn1 was detected only in the thick ascending limb (TAL) of HL. In addition, the expression of a number of TAL-specific genes was reduced in the Brn1+/- kidney, including Umod,Nkcc2/Slc12a1, Bsnd, Kcnj1 and Ptger3. These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney.
- RIKEN Brain Science Institute Japan
- RIKEN Japan
- Tohoku University Japan
- Japanese Foundation For Cancer Research Japan
Mice, Knockout, Potassium Channels, Sodium-Potassium-Chloride Symporters, Neuropeptides, Gene Dosage, Membrane Proteins, Nerve Tissue Proteins, Mice, Mucoproteins, Animals, Newborn, Chloride Channels, Pregnancy, POU Domain Factors, Receptors, Prostaglandin E, EP3 Subtype, Animals, Receptors, Prostaglandin E, Female, Renal Insufficiency, Potassium Channels, Inwardly Rectifying, Kidney Tubules, Distal
Mice, Knockout, Potassium Channels, Sodium-Potassium-Chloride Symporters, Neuropeptides, Gene Dosage, Membrane Proteins, Nerve Tissue Proteins, Mice, Mucoproteins, Animals, Newborn, Chloride Channels, Pregnancy, POU Domain Factors, Receptors, Prostaglandin E, EP3 Subtype, Animals, Receptors, Prostaglandin E, Female, Renal Insufficiency, Potassium Channels, Inwardly Rectifying, Kidney Tubules, Distal
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