Tissue Antigens
Article . 2000 . Peer-reviewed
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Identification of a novel HLA‐Cw*O7 variant (Cw*0714) in a German Caucasian family

Authors: Lourdes Places; A. Hummler; Idoia Gimferrer; Jordi Vives; Josep M. Vilà; M.T. Arias; Francisco Lozano; +2 Authors
Lourdes Places; A. Hummler; Idoia Gimferrer; Jordi Vives; Josep M. Vilà; M.T. Arias; Francisco Lozano; Jaume Martorell; Gerhard Ehninger;
Identification of a novel HLA‐Cw*O7 variant (Cw*0714) in a German Caucasian family
Abstract
We report herein the identification of a new HLA‐Cw*07 allele in two members of a German Caucasian family. This novel allele, designated as Cw*0714, differs from Cw*07011 and Cw*0706 by two nucleotide changes: one at codon 66 (AAC→AAG) in the exon 2, leading to an amino acid change from Asn to Lys; and another silent substitution at codon 99 (TAT→TAC) in the exon 3. The latest substitution (T→C at the third position of codon 99) was not seen in any of the HLA‐Cw*07 alleles reported so far, thus being characteristic to the new HLA‐Cw*0714 allele ( Note).
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