Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1
Copyright policy )Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1
In this study, we examined the role of sphingosine-1-phosphate (S1P) in regulating the transcription of the liver receptor homologue-1 (LRH-1) in breast cancer cells. We show that S1P induces LRH-1 mRNA expression in MCF-7 cells in a prostaglandin E2 (PGE2)-dependent manner. Both S1P and PGE2 stimulate the recruitment of LRH-1, cAMP response element binding protein (CREB), CCAAT/enhancer binding proteins (C/EBP), and RNA Polymerase II (Pol II) to the LRH-1 promoter, as well as increase acetylation of histone H3 in this region of chromatin. S1P and PGE2 promote the direct interaction of CREB and LRH-1, which is potentiated by C/EBPdelta and the coactivators CREB-binding protein (CBP), and steroid receptor coactivator-3 (SRC-3). CREB and LRH-1 synergistically increase LRH-1 transcription, suggesting an integral role for LRH-1 in regulating the transcription of its own gene.
- Georgia Institute of Technology United States
Base Sequence, Molecular Sequence Data, Receptors, Cytoplasmic and Nuclear, Acetylation, Dinoprostone, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Histones, Mice, Cyclooxygenase 2, Genes, Reporter, Cell Line, Tumor, NIH 3T3 Cells, Animals, Humans, RNA, Messenger, Lysophospholipids, Cyclic AMP Response Element-Binding Protein, Promoter Regions, Genetic, Protein Binding
Base Sequence, Molecular Sequence Data, Receptors, Cytoplasmic and Nuclear, Acetylation, Dinoprostone, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Histones, Mice, Cyclooxygenase 2, Genes, Reporter, Cell Line, Tumor, NIH 3T3 Cells, Animals, Humans, RNA, Messenger, Lysophospholipids, Cyclic AMP Response Element-Binding Protein, Promoter Regions, Genetic, Protein Binding
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