Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses
Copyright policy )Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses
Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5′cap-0 structure for optimal evasion of the host innate immune system. In this paper, we seek to discuss the various methyltransferases that exist within single-stranded RNA (ssRNA) viruses along with their respective inhibitors. Additionally, the importance of motifs such as the KDKE tetrad and glycine-rich motif in the catalytic activity of methyltransferases is discussed.
- University of Florida United States
- University of Florida United States
KDKE tetrad, Review, Methyltransferases, Virus Replication, Microbiology, Antiviral Agents, QR1-502, Catalysis, methyltransferase inhibitors, Humans, RNA Viruses, methyltransferase, Enzyme Inhibitors, Immune Evasion
KDKE tetrad, Review, Methyltransferases, Virus Replication, Microbiology, Antiviral Agents, QR1-502, Catalysis, methyltransferase inhibitors, Humans, RNA Viruses, methyltransferase, Enzyme Inhibitors, Immune Evasion
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