Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression
Copyright policy )Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression
Significance Caenorhabditis elegans studies have contributed greatly to our understanding of the temporal regulation of development. These studies led to the discovery of microRNAs (miRNAs) and revealed that a succession of stage-specifically expressed miRNAs act as switches to guide life-stage transitions in cell fates. These miRNAs are conserved to humans and cause disease states when misexpressed, highlighting the importance of their temporal regulation. Much is known about the biogenesis and function of miRNAs, but how these processes are temporally sculpted is not well understood. This study reports that LIN-42, the C. elegans homolog of the circadian rhythm protein Period, regulates timing of miRNA expression by modulating transcription. These findings further our understanding of the functions of developmental timekeepers and regulation of miRNAs.
- University of Minnesota System United States
- University of Minnesota United States
- University of Minnesota Morris United States
Time Factors, Sequence Homology, Amino Acid, Green Fluorescent Proteins, Gene Expression Regulation, Developmental, Epistasis, Genetic, Period Circadian Proteins, MicroRNAs, Larva, Multigene Family, Mutation, Animals, RNA, Messenger, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Transcription Factors
Time Factors, Sequence Homology, Amino Acid, Green Fluorescent Proteins, Gene Expression Regulation, Developmental, Epistasis, Genetic, Period Circadian Proteins, MicroRNAs, Larva, Multigene Family, Mutation, Animals, RNA, Messenger, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Transcription Factors
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