Control of MT1-MMP transport by atypical PKC during breast-cancer progression
Copyright policy )Control of MT1-MMP transport by atypical PKC during breast-cancer progression
Significance We characterize a mechanism through which the polarity protein atypical PKCι controls invasion and matrix remodeling by tumor cells by regulating endosome-to-plasma membrane traffic of the membrane type 1-matrix metalloproteinase (MT1-MMP) in breast-cancer cells. Further analysis shows that atypical PKCι and MT1-MMP are co–up-regulated in hormone receptor-negative breast tumors in association with higher risk of metastasis. These findings provide previously unidentified avenues for the design of therapeutic interventions.
actin cytoskeleton, TUMOR-CELLS, Dynamin II, Breast cancer, MT1-MMP, https://purl.org/becyt/ford/3.1, EXTRACELLULAR-MATRIX DEGRADATION, RNA, Neoplasm, RNA, Small Interfering, Phosphorylation, Protein Kinase C, Atypical PKC, MMP14, Actin cytoskeleton, Carcinoma, Ductal, Breast, 600, Middle Aged, Membrane traffic, Up-Regulation, multi-vesicular body, Extracellular Matrix, [SDV] Life Sciences [q-bio], Multidisciplinary Sciences, Isoenzymes, Disease Progression, Science & Technology - Other Topics, RNA Interference, Female, METALLOPROTEINASE, Multi vesicular body, Cortactin, POLARITY, EXPRESSION, Adult, 570, DYNAMIN, Tumor invasion, Biological Transport, Active, Breast Neoplasms, membrane traffic, Endosomes, Adenocarcinoma, Cytoplasmic Granules, INVADOPODIA FORMATION, Cell Line, Tumor, Matrix Metalloproteinase 14, CELL INVASION, Humans, Neoplasm Invasiveness, https://purl.org/becyt/ford/3, RNA, Messenger, Aged, Science & Technology, CORTACTIN, METASTASIS, OVEREXPRESSION
actin cytoskeleton, TUMOR-CELLS, Dynamin II, Breast cancer, MT1-MMP, https://purl.org/becyt/ford/3.1, EXTRACELLULAR-MATRIX DEGRADATION, RNA, Neoplasm, RNA, Small Interfering, Phosphorylation, Protein Kinase C, Atypical PKC, MMP14, Actin cytoskeleton, Carcinoma, Ductal, Breast, 600, Middle Aged, Membrane traffic, Up-Regulation, multi-vesicular body, Extracellular Matrix, [SDV] Life Sciences [q-bio], Multidisciplinary Sciences, Isoenzymes, Disease Progression, Science & Technology - Other Topics, RNA Interference, Female, METALLOPROTEINASE, Multi vesicular body, Cortactin, POLARITY, EXPRESSION, Adult, 570, DYNAMIN, Tumor invasion, Biological Transport, Active, Breast Neoplasms, membrane traffic, Endosomes, Adenocarcinoma, Cytoplasmic Granules, INVADOPODIA FORMATION, Cell Line, Tumor, Matrix Metalloproteinase 14, CELL INVASION, Humans, Neoplasm Invasiveness, https://purl.org/becyt/ford/3, RNA, Messenger, Aged, Science & Technology, CORTACTIN, METASTASIS, OVEREXPRESSION
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