Genetic Basis for Conversion of Rough-to-Smooth Colony Morphology in Actinobacillus actinomycetemcomitans
Copyright policy )Genetic Basis for Conversion of Rough-to-Smooth Colony Morphology in Actinobacillus actinomycetemcomitans
ABSTRACT The basis of the rough-to-smooth conversion of Actinobacillus actinomycetemcomitans was examined. Smooth variants often contained mutations at the flp promoter region. Replacing the mutated flp promoter with the wild-type promoter restored the rough phenotype. The expression level of the flp promoter was ∼100-fold lower in smooth than in rough strains. Mutations of the flp promoter are a cause of the rough-to-smooth conversion.
- University of Southern California United States
- University of California System United States
Bacterial Proteins, Base Sequence, Microscopy, Electron, Transmission, Molecular Sequence Data, Promoter Regions, Genetic, Aggregatibacter actinomycetemcomitans
Bacterial Proteins, Base Sequence, Microscopy, Electron, Transmission, Molecular Sequence Data, Promoter Regions, Genetic, Aggregatibacter actinomycetemcomitans
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