GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response
Copyright policy )GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response
Glutathione peroxidase 3 (GPx3), a plasma antioxidant enzyme, maintains genomic integrity by inactivating reactive oxygen species (ROS), known DNA-damaging agents and mediators of cancer chemotherapy response. In this study, we demonstrate that loss of GPx3 expression by promoter hypermethylation is frequently observed in a wide spectrum of human malignancies. Furthermore, GPx3 methylation correlates with head and neck cancer (HNC) chemoresistance and may serve as a potential prognostic indicator for HNC patients treated with cisplatin-based chemotherapy. Our findings support the hypothesis that defects in the antioxidant system may contribute to tumorigenesis of a wide spectrum of human malignancies. GPx3 methylation may have implications in chemotherapy response and clinical outcome of HNC patients.
- Indiana University United States
- University of Maryland, Baltimore United States
- University of Maryland Marlene and Stewart Greenebaum Cancer Center United States
- University of Maryland School of Medicine United States
- University of Maryland Medical System United States
Male, Glutathione Peroxidase, Down-Regulation, Antineoplastic Agents, DNA Methylation, Prognosis, Polymerase Chain Reaction, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Treatment Outcome, Head and Neck Neoplasms, Cell Line, Tumor, Neoplasms, Humans, Female
Male, Glutathione Peroxidase, Down-Regulation, Antineoplastic Agents, DNA Methylation, Prognosis, Polymerase Chain Reaction, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Treatment Outcome, Head and Neck Neoplasms, Cell Line, Tumor, Neoplasms, Humans, Female
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